Saints make the short trip to Brighton looking to build on their win over Cardiff last week.
Both teams go into the game on the back of good victories; The Seagulls beat Millwall 2-0 in their last game.
Brighton are boosted by the return of Alex Frutos, while Gary hart is also expected to figure despite picking up a facial injury in the win over Millwall.
Danny Higginbotham will be missing with both a broken wrist and leg injury, he’ll be out for around two weeks. Darren Powell should be fit to replace him in defence.
Darren Kenton is also sideliend with a hamstring injury and Matt Oakley hasn’t recovered from his ankle injury.
Alexander Ostlund and Nathan Dyer are both set to return for Saints.
Fuller is likely to keep his place up front after scoring twice on his surprise return to Saints in the 3-2 win over Cardiff last week.