Both players picked up knocks in the game versus Wigan Athletic and were substituted.
RamÃrez was set to be part of Uruguay`s match against Spain in Qatar on Wednesday, whilst Clyne had been called into the England Under-21 squad set to face Sweden.
Their withdrawal still leaves us with seven players still involved with the internationals. They are Artur Boruc, Steven Davis, Vegard Forren, Calum Chambers, James Ward-Prowse, Lloyd Isgrove and Luke Shaw.
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